Biomolecular Chemistry Laboratory

We make innovative research tools from fluorescent proteins

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Innovative Research Tools from Fluorescent Proteins

We use protein engineering to invent new tools for imaging dynamic biochemical events in live cells and tissues. We distribute these tools to cell biologists and neuroscientists who apply them to address questions ranging from fundamental mechanisms in cell biology, to the underlying causes of mental illness, to the development of novel therapeutics.


The molecules that make our work possible are colourful naturally occurring fluorescent proteins from jellyfish, coral, and other marine organisms. Starting from the gene for a fluorescent protein, we use the techniques of molecular biology, protein engineering, and artificial molecular evolution to create useful research tools. Since these tools are protein based, the instructions to make them can be easily introduced into cells, tissues, or even transgenic model organisms, in the form of DNA.

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  • The interview with Dr. Campbell has now been published on the School of Science website

    The interview with Dr. Campbell is now available on the School of Science’s Rigakuru website. Please access the article through the link below. 英語：The Future of Seeing Life:How Chemigenetic Tools are Transforming Biological Imaginghttps://www.s.u-tokyo.ac.jp/en/rigakuru/research/yfZAebTe/ 日本語：生命を見つめて:化学遺伝学ツールが切り拓くバイオイメージングの未来https://www.s.u-tokyo.ac.jp/ja/rigakuru/research/yfZAebTe/

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  • Dazhou’s recent paper is now highlighted in the Rigakubu News

    Dazhou’s recent paper on his chemigenetic sensors is now highligted in the Rigakubu News (School of Science magazine). Please check the link below. Dazhouさんの化学遺伝学センサーに関する研究成果が理学部ニュースに取り上げられました。下のリンクからぜひご覧ください。 English version: https://www.s.u-tokyo.ac.jp/en/story/newsletter/page/10724 日本語版: https://www.s.u-tokyo.ac.jp/ja/story/newsletter/page/10724

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