Biomolecular Chemistry Laboratory

We make innovative research tools from fluorescent proteins

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Innovative Research Tools from Fluorescent Proteins

We use protein engineering to invent new tools for imaging dynamic biochemical events in live cells and tissues. We distribute these tools to cell biologists and neuroscientists who apply them to address questions ranging from fundamental mechanisms in cell biology, to the underlying causes of mental illness, to the development of novel therapeutics.


The molecules that make our work possible are colourful naturally occurring fluorescent proteins from jellyfish, coral, and other marine organisms. Starting from the gene for a fluorescent protein, we use the techniques of molecular biology, protein engineering, and artificial molecular evolution to create useful research tools. Since these tools are protein based, the instructions to make them can be easily introduced into cells, tissues, or even transgenic model organisms, in the form of DNA.

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  • A new paper on far-red fluorescent genetically encoded calcium indicators is now published!

    Our new research paper, “Far-red fluorescent genetically encoded calcium ion indicators”, is now published in Nature Communications. Congratulations, Dr. Dalangin and co-authors! The paper can be accessed here. Dr. Dalanginらによる遠赤色蛍光のカルシウムセンサーに関する論文が Nature Communications に掲載されました。おめでとうございます！論文はこちらからご覧いただけます。

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  • A paper on a photocaged-L-lactate is now published!

    Our new research paper, “Synthesis and application of a photocaged-L-lactate for studying the biological roles of L-lactate”, is now published in Communications Chemistry. Congratulations, Ikumi and co-authors! The paper can be accessed here. 宮崎さんらによる光ケージド乳酸に関する論文がCommnications Chemistry誌に掲載されました。おめでとうございます! 論文はこちらから。

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